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Pharmacology: Pharmacokinetics: Absorption of Medroxyprogesterone acetate (MPA) and Estradiol cypionate (17β-estradiol; E2) from the injection site is prolonged after an intramuscular injection of Depo Monat. The time to maximum plasma concentration (Tmax) typically occurs within 1 to 10 days post-injection for MPA and 1 to 7 days post-injection for E2 (17β-estradiol).
Elimination half life: Residual Medroxyprogesterone acetate (MPA) concentrations at the end of monthly injection of Depo Monat are generally below 0.5 ng/ml, consistent with its apparent elimination half life of 15 days. Most MPA metabolites are excreted in the urine as glucuronide conjugates with only small amount excreted as sulfates. Following the peak concentration, serum E2 levels typically decline to 100 pg/ml by day 14 and are consistent with the apparent elimination half life of 7 to 8 days. Estrogen metabolites are primarily excreted in the urine as glucuronide and sulfates.
